PROTEIN MODELLING, RATIONAL DRUG DESIGN
Course Length : Regular - 90 Days, Fastrack - 60 Days
Course Start : For Details Call +91 9247716307,
Limited seats per batch
Course Location : Hyderabad, India
Contact Us : Call +91 9247716307
 

Syllabus

 
  • Alignments and structure prediction tools
  • Alignment methodologies, limitations, problems
  • TM and secondary structure prediction
  • Full structure prediction - current status
  • Practical: predicting structure
  • Introduction to Drug Design and Development
  • Target Selection and Validation¬†
  • Lead Identification and Modification
  • Computer-Aided Drug Design
  • Drug Delivery
  • Pre-clinical and Clinical Testing
  • Introduction to Rational Drug Designing.
  • Molecular modeling
  • Force fields
  • Potential energy functions
  • Energy minimization Methods
  • Global and Local energy minimization
  • Conformational search methods
  • Molecular dynamics and Monte Carlo simulations
  • Sequence analysis and Applications
  • Pairwise and Multiple sequence alignment
  • Homology Modeling of Proteins
  • Ramachandranplot analysis,Procheck and Profiles3d
  • Active site Pocket identification
  • Structure based drug designing
  • Docking studies
  • Protein-ligand docking studies
  • Protein-Protein interactions
  • Virtual screening
  • HTS
  • Hit to lead selection and validation
  • Ligand Based drug designing or QSAR studies
  • 2D and 3D QSAR (COMFA and COMSIA)studies
  • Denovo Drug Designing
  • Interaction Map generation
  • Pharmacophore studies
  • ADME/Toxicity calculations
  • FDA in drug trials
 

Overview

 
Protein modelling and rational drug designing is now a popular technique used for increasing the speed of drug designing process. This was made possible by the availability of many protein structures which helped in developing tools to understand the structure function relationships, automated docking and virtual screening.
 

Eligibility

 
  • Ph.Ds in any science discipline
  • Postgraduates with specialization in any of the areas of molecular biology, genetics, microbiology, structural biology, genetics, chemistry, physics, statistics and biotechnology.
  • B. Pharm, M. Pharm, MBBS, MD, BE/B. Tech, ME/M.Tech etc.
  • Final year students of the above courses as a part of fulfilling their project work.
  • Students looking for Research opportunities abroad.
  • Research Scholars in any areas of life & chemical sciences.
  • Bachelors in Biotechnology, Microbiology, Bioinformatics, Life sciences, Biochemistry, Zoology, Botany and related discipline.
 

Course Goal


The course aims at providing the participants with basic modern structural bioinformatics and homology-based protein modeling, understanding of computational modeling in the area of drug discovery. After finishing the course the participants will have:

  • Basic understanding of ligand-protein interactions.
  • Use Internet-based structural bioinformatics tools to analyse three-dimensional structures of a proteins and a protein-ligand complexes and perform homology-based modeling.
  • Understand the general principles behind protein crystallization and X-Ray crystallography assess the requirements and take active part in the planning and the subsequent development of this type of projects.
  • Be familiar with a range of ligand and structure based computational methods.
  • Perform simple computational modeling tasks using state of the art software.
  • Hands-on training in the use of industry-standard tools with complete suite of software & programs.
 
 
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